Journal: Bioactive Materials

Article Title: Decellularized extracellular matrix materials for treatment of ischemic cardiomyopathy

doi: 10.1016/j.bioactmat.2023.10.015

Figure Lengend Snippet: Approved dECM medical devices and devices under clinical trials.

Article Snippet: A SIS dECM patch product, CorPatch (CorMatrix Cardiovascular, Inc) has been approved by FDA.

Techniques: Clinical Proteomics

Journal: Bioactive Materials

Article Title: Decellularized extracellular matrix materials for treatment of ischemic cardiomyopathy

doi: 10.1016/j.bioactmat.2023.10.015

Figure Lengend Snippet: A commercial epicardial patch for ICM. (A) The CorPatch sheet with 4-layer structure and its components. (B) CorPatch was used as an epicardial patch for infarct myocardial repair. Modified and adapted with permission from Ref. . Copyright 2023, Future Science Group. (C) Cardiac MRI images and regional myocardial perfusion of human left ventricle treated by CorPatch at baseline, 6 week and 6 month. Modified and adapted with permission from Ref. . Copyright 2023, Springer Nature.

Article Snippet: A SIS dECM patch product, CorPatch (CorMatrix Cardiovascular, Inc) has been approved by FDA.

Techniques: Modification

Journal: International Journal of Molecular Sciences

Article Title: Dye-Mediated Photo-Oxidation Biomaterial Fixation: Analysis of Bioinductivity and Mechanical Properties of Bovine Pericardium for Use in Cardiac Surgery

doi: 10.3390/ijms221910768

Figure Lengend Snippet: Dye-Mediated Photo-Oxidation (DMPO)-fixed ECM Bioscaffold Promotes a Pro-Vasculogenic Paracrine Response from Human Cardiac Fibroblasts Similar to Bioactive Small Intestinal Submucosa (SIS) ECM Bioscaffold. Multiplex analysis of fibroblast growth factor-2 (FGF-2), hepatocyte growth factor (HGF), fibroblast growth factor-1 (FGF-1), vascular endothelial growth factor-A (VEGF-A), and vascular endothelial growth factor-C (VEGF-C) from conditioned media from human cardiac fibroblasts on tissue culture plastic (control; N = 7), bioactive SIS-ECM (N = 7), or DMPO-fixed ECM bioscaffold (N = 7). Values represent mean ± SEM, baseline-corrected to control. Statistical significance determined by unpaired Student’s t -test; symbols denote statistical significance (* = p -value < 0.05).

Article Snippet: Additionally, given the hypothesized bioinductivity of this material, we compared the paracrine activity of human cardiac fibroblasts seeded on DMPO-fixed bovine pericardium with those seeded on known bioactive SIS-ECM (Cor TM PATCH; CorMatrix Cardiovascular Inc., Roswell, GA, USA).

Techniques: Multiplex Assay, Control

Journal: Advanced healthcare materials

Article Title: Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration

doi: 10.1002/adhm.201801217

Figure Lengend Snippet: Solid dECM scaffolds with cells.

Article Snippet: In addition, solid SIS patches (CorMatrix) and injectable cECM hydrogels (Ventrigel have moved toward clinical treatment of cardiovascular dysfunction, although challenges and considerations remain.

Techniques: Migration, Derivative Assay

Journal: Advanced healthcare materials

Article Title: Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration

doi: 10.1002/adhm.201801217

Figure Lengend Snippet: Large animal models in dECM cardiac therapy.

Article Snippet: In addition, solid SIS patches (CorMatrix) and injectable cECM hydrogels (Ventrigel have moved toward clinical treatment of cardiovascular dysfunction, although challenges and considerations remain.

Techniques: Formulation, Animal Model, Injection, Saline

Journal: Frontiers in Pediatrics

Article Title: Is Decellularized Porcine Small Intestine Sub-mucosa Patch Suitable for Aortic Arch Repair?

doi: 10.3389/fped.2018.00149

Figure Lengend Snippet: CT scan with 3D reconstruction showing the hypoplastic aortic arch two and half year after DPSIS patch arch reconstruction.

Article Snippet: After experimental ( – ) and clinical ( – ) studies, the decellularized porcine small intestine sub-mucosa (DPSIS) patch has been introduced with the commercial name of CorMatrix® (CorMatrix Cardiovascular, Roswell, GA) for the surgical treatment of congenital heart defects, with implantations performed for closure of septal defects, valve repair, and as vascular patch in both the systemic and pulmonary circulations ( – ).

Techniques: Computed Tomography

Journal: Frontiers in Pediatrics

Article Title: Is Decellularized Porcine Small Intestine Sub-mucosa Patch Suitable for Aortic Arch Repair?

doi: 10.3389/fped.2018.00149

Figure Lengend Snippet: CT scan with 3D reconstruction showing the hypoplastic aortic arch two and half year after DPSIS patch arch reconstruction.

Article Snippet: The company (CorMatrix Cardiovascular, Roswell, GA) claimed, in the official advertising of the patch, the ability of the DPSIS patch to regrow and remodel, constituting a structurally support gradually replaced by native tissues, leaving no foreign material behind, encouraging the body's natural immune response, allowing capillary in-growth and infiltration of white blood cells into newly remodeled tissue, and avoiding inflammation and scarring (CorMatrix®).

Techniques: Computed Tomography

Journal: Advanced healthcare materials

Article Title: Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration

doi: 10.1002/adhm.201801217

Figure Lengend Snippet: Main terminology used to differentiation dECM technologies. Examples: (Top left - patches) Reproduced with permission.[103] Copyright 2008, Springer Nature. (Bottom left - injectable hydrogels) Reproduced with permission.[131] Copyright 2011, National Academy of Sciences. (Top right - whole hearts) Reproduced with permission.[37] Copyright 2018, Wiley-VCH. (Bottom right - patches) Reproduced with permission.[73] Copyright 2016, Elsevier.

Article Snippet: Porcine SIS , Solid dECM patch—CorMatrix , Pig coronary ischemia , Treatment with SIS patch epicardially 75 min postischemia, followed through 6 weeks, compared outcomes to 1 week baselines and sham Improved wall and epicardial thickness, angiogenesis in infarct No change in fibrosis , [ 142 ].

Techniques:

Journal: Advanced healthcare materials

Article Title: Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration

doi: 10.1002/adhm.201801217

Figure Lengend Snippet: Comparison of various dECM versus cECM.

Article Snippet: Porcine SIS , Solid dECM patch—CorMatrix , Pig coronary ischemia , Treatment with SIS patch epicardially 75 min postischemia, followed through 6 weeks, compared outcomes to 1 week baselines and sham Improved wall and epicardial thickness, angiogenesis in infarct No change in fibrosis , [ 142 ].

Techniques: Comparison, Pore Size, In Vivo, Migration

Journal: Advanced healthcare materials

Article Title: Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration

doi: 10.1002/adhm.201801217

Figure Lengend Snippet: Solid dECM scaffolds with cells.

Article Snippet: Porcine SIS , Solid dECM patch—CorMatrix , Pig coronary ischemia , Treatment with SIS patch epicardially 75 min postischemia, followed through 6 weeks, compared outcomes to 1 week baselines and sham Improved wall and epicardial thickness, angiogenesis in infarct No change in fibrosis , [ 142 ].

Techniques: Migration, Derivative Assay

Journal: Advanced healthcare materials

Article Title: Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration

doi: 10.1002/adhm.201801217

Figure Lengend Snippet: Pure Decm-stem cell interactions.

Article Snippet: Porcine SIS , Solid dECM patch—CorMatrix , Pig coronary ischemia , Treatment with SIS patch epicardially 75 min postischemia, followed through 6 weeks, compared outcomes to 1 week baselines and sham Improved wall and epicardial thickness, angiogenesis in infarct No change in fibrosis , [ 142 ].

Techniques: Formulation, Expressing, Migration

Journal: Advanced healthcare materials

Article Title: Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration

doi: 10.1002/adhm.201801217

Figure Lengend Snippet: Combinatorial soluble dECM-biomaterial scaffolds.

Article Snippet: Porcine SIS , Solid dECM patch—CorMatrix , Pig coronary ischemia , Treatment with SIS patch epicardially 75 min postischemia, followed through 6 weeks, compared outcomes to 1 week baselines and sham Improved wall and epicardial thickness, angiogenesis in infarct No change in fibrosis , [ 142 ].

Techniques: In Vivo, Concentration Assay, Expressing, Membrane, Preserving

Journal: Advanced healthcare materials

Article Title: Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration

doi: 10.1002/adhm.201801217

Figure Lengend Snippet: Large animal models in dECM cardiac therapy.

Article Snippet: Porcine SIS , Solid dECM patch—CorMatrix , Pig coronary ischemia , Treatment with SIS patch epicardially 75 min postischemia, followed through 6 weeks, compared outcomes to 1 week baselines and sham Improved wall and epicardial thickness, angiogenesis in infarct No change in fibrosis , [ 142 ].

Techniques: Formulation, Animal Model, Injection, Saline

Journal: International Journal of Molecular Sciences

Article Title: Progress in Bioengineering Strategies for Heart Regenerative Medicine

doi: 10.3390/ijms23073482

Figure Lengend Snippet: Schema of the latest biomaterials and biofabrication technologies for the generation of engineered heart muscles. 3D, three-dimensional; BP, bioprinting; EC, endothelial cell; ECM, extracellular matrix; EHT, engineered heart tissue; FRESH, freeform reversible embedding of suspended hydrogels; PDMS, polydimethylsiloxane; SWIFT, sacrificial writing into functional tissue. 1. Hydrogels: In situ gelling [ , ], Epicardial patch [ , ], Cell/biomolecule encapsulation [ , ], Casting molds [ , ]; 2. Deculllarized Bioscaffolds : ECM bioscaffolds [ , ]; 3. Microfabrication Technologies: Electronic cardiac patch , Patterning (on PDMS) , Angiochip , Anisotropic cardiac patch [ , ], Self-organizing patterned michrochamber , Electrospinning [ , ], Microfluidic chip , Muscle strip (ring shaped EHT) , Dynamic culture (cardiobundles) , Micro heart muscle arrays , Biowire TM [ , ]; 4. Organoids : Cardiac organoids [ , ]; 5. Bioprinting: Extrusion based multimaterial BP , FRESH BP [ , ], Stereolitography based BP of vasculature , Multiphoton-excited 3D BP , BP of microfibrous scaffold & ECs , SWIFT BP .

Article Snippet: Focusing on the restoration of ECM homeostasis and structure in the heart environment, other clinical trials evaluating the therapeutic effects of ECM epicardial patches (CorMatrix TM -ECM; porcine small intestinal submucosa-derived) [ , , ] or cardiac ECM hydrogels (VentriGel; decellularized porcine myocardium-derived) [ ] to the recent or late infarcted hearts have recently been completed.

Techniques: Muscles, Functional Assay, In Situ, Encapsulation, Stripping Membranes

Journal: International Journal of Molecular Sciences

Article Title: Progress in Bioengineering Strategies for Heart Regenerative Medicine

doi: 10.3390/ijms23073482

Figure Lengend Snippet: The selected in vivo preclinical studies and human clinical trials of cardiac tissue engineering-based therapies for heart regeneration and repair. CABG, coronary artery bypass grafting; CM, cardiomyocyte; EC, endothelial cell; ECM, extracellular matrix; EF, ejection fraction; EHM, engineered heart muscle; hESC, human embryonic stem cell; hiPSC, human inducible pluripotent stem cell; HF, heart failure; IGF, insulin-like growth factor; IJ, injection; IR, ischemia reperfusion injury; MI, myocardial infarction; PLGA, poly(lactic- co -glycolic acid); PNIPAAm, poly(N-isopropylacrylamide); SMC, smooth muscle cell.

Article Snippet: Focusing on the restoration of ECM homeostasis and structure in the heart environment, other clinical trials evaluating the therapeutic effects of ECM epicardial patches (CorMatrix TM -ECM; porcine small intestinal submucosa-derived) [ , , ] or cardiac ECM hydrogels (VentriGel; decellularized porcine myocardium-derived) [ ] to the recent or late infarcted hearts have recently been completed.

Techniques: In Vivo, Clinical Proteomics, Injection, Stripping Membranes, In Situ, Preserving